The answer to your question is "Yes".
One of the best Benchrest Shooters around, a noted Gulf Coast Region Shooter, uses his own method of eccentially indicating the first inches, (I don't know how many), of the chamber end. Yes, the muzzle will run out according to how much variation is present in the barrels ID with it's own self, but it is of no consequense. The chamber he establishes will be dead on true with that first section of barrel, and the results do speak for themselves as his Rifles consistantly perform at the top.
Skeet, keep in mind, if a barrel's ID were perfectly straight with it's self, it would all be a moot point. Rememeber, once the bullet makes that initial engrave into the lands and grooves upon igintion, it will follow what ever is present in the rest of the ID.
I prefer my method, because it suites the equipment I have on hand, and, well, I just prefer it.
Where I differ, well downright disagree, with some Craftsmen is this whole thing of barrel indexing. I have proven to myself that a barrels ID is not "bent" as in a bannana bend. It has various spots that for what ever reason known only to Gun Drills, the ID wonders, one run out spot may be in one direction, six inches further up one might be in another. So, I think all of this "barrel indexing" is bogus. People are paying for something that is based on junk science...........jackie