Maybe
I have mixed 130 and 133, and it shot like 132, if there ever was such an animal.
More than a few shooters do mix powders. I stopped because it didn't do anything special. But there are two Famous Brothers up in the east that mix powders, and do very well.
The key is to get an even dispersion. I put mine in the tumbler that I used to lube bullet jackets in, and blended it 50-50.
One thing I thought about doing was getting two small measures, fill one with one powder, and the other with another. Then, throw 14 or so grns out of each into a container, shake it up, and put it into the case. At least you would be sure that you did have a 50-50 mix of what ever you were using,.......jackie