To answer your question
I feel that running no more then 3100fps at the correct twist is a nice safe max. I think the most accurate velocity falls in the 2800 to 3000fps range. Of course, there are instances where these very heavy for cal bullets have been run significantly faster but there should be 100% success at this level of performance.
I think you will find that barrels will have an enormous effect on your results.
I have had several barrels that ATE bullets well below speeds that others were shooting. Other barrels that shot their best accuracy at well below expected maximums.
In LR shooting, I prefer the highest BC bullet at the highest velocity that I can handle the recoil for. Wind is my biggest enemy and can turn a 1/4min rifle into a 'Where's the bullet hole?".
Jerry