One of the reasons that people try to find the "jam length" for a bullet is that if loads are developed with the bullet at the rifling, the only way to go with the bullet is deeper in the case. Concentricity should be taken care of with the sizing and bullet seating steps, so after they're sorted out, seating depths are the last step in load refinement. The bullet shape has something to do with where the bullet likes to be. Some bullets (VLD's) with large radius ogives (pointier bullets) generally like to be seated in or close to the rifling, while "standard" bullets aren't usually as particular.
I was told by a gunsmith that rifles with steep throats (larger included angle) tend to like their bullets seated farther from the rifling, and in one rifle I was having problems with he seemed to be correct.