Boyd,
As was pointed out to me last year by friend and gunsmith Bob Kingsbury,It is not at all uncommon for a seating stem and top assembly to be"out". If you use a concentricity gauge to check runout,indexing the seater top around the clock you will ( with a top and stem that are "out")find runout get better or worse depending on clock position.An index mark at the best position is the cheap fix.Countless hours truing up your die set-up is the best fix and to quote Bob "that's why it's always been a gunsmiths game".Seating depth variations can be caused by this same unchecked rotation of the "out" seater stem/top assembly as well as by other variations that Hovis,and Jerry mentioned.
I am not a gunsmith ,I'm just a shooter, so my solution to the problem is a lot less refined. Find a competitive seating depth that is not so damned critical !
Different guys set up their guns differently.Some guys use loose neck tension, seat the bullet .010 past jam and let the chamber finish the job,some guys use heavy neck tension,hard jam and all the 133 they can get in a case, some guys use moderate neck tension,make a square mark and play with powder,etc,etc,etc. I prefer moderate neck tension,moderate powder charge and will start at jam and work my way back to jump and beyond in .005 increments. As Jerry was talking about you'll see the groups get bigger and smaller. If you look a little deeper you might see( all barrels are different) two or three settings that perform just as well as each other,right next to each other,that's what I'm lookin for( maybe .010,.015 and .020 off jam ?)take the.015 setting and put the powder to it,now take some powder away. You might find that.015 shoots 52,53 and 54 of 133 all real tight and all in the same hole, now stretch the seating depth longer and shorter in smaller increments at the different powder charges,does the gun still drill ?, at what point does it come apart? If you take a "middle ground" tuned rifle to the line it will be less sensitive to changes in environment and performance. If you need to make adjustments you'll rarely be lost. You've already put the gun through it's paces during initial set-up and evaluation.
If your barrel only has one spot that shoots( let's say .005 off jam and 55cl of 133)and at 54 or 56 it justs globs,or at jam or .010 off it just spits.Well,that's not much of a tune.And sooner or later it's gonna come apart on ya and you're gonna be lost.
I know you've been at this awhile and probably know this stuff,so my response is really for the benefit of the new guys that think there is only one way to tune,cause that's what "so and so" told them about 10 years ago.
Joel