I don't advocate blending powder "for people who do not know". I said err on the safe side, stick to the cookbook. But, people who "do know" blend powders on purpose, also, people make up duplex loads, even triplex loads. people do this for many reasons. Top performance from a specific arm, use up a whole bunch of powder which won't give the desired results by itself, etc. If you are loading for a .243 with an 18 inch barrel you may use a different powder than for a 26 inch barrel. People reload for all kinds of reasons. I have a friend who has reloaded for 40 years. He loads for a 30-06and uses a lee loader. He uses the same load all the time. He loads to reduce recoil and save money. Advance loaders understand the relationship between case capacity, bore diameter, barrel length, burnrate, bullet weight, bullet coating and bearing length, and how all this effects the time pressure curve. Called interior ballistics, it is a known science and has been at the state of the art since Paul Mauser's time. details change, but the math is the same. The guy who road down to the gun show with me on Sat. has been around alot onger than I have. He said that once they had vast quantities of 50 BMG powder and were using it in large straight walled cases. Totally unsuited powder. But, they wanted to shoot. So they kick started it with bullseye and got an acceptable level of performance.