Al, I agree there is a lot that goes into reloading in case prep, technique, concentricity, seating depth, twist, etc., but there are some powder and primer combinations in a given case capacity behind a certain projectile that will just stand out.
And there are some standout loads that seem to be almost universal. I've seen my favorite .223 ground hog load shoot holes touching 3 shot groups over and over out of 3 different CZ527's, a Savage, a Browning, and a Remington 7. All had ~22 inch sporter barrels. Some bedded, some not, didn't seem to matter. 40g NBT seated ~0.020 off the lands, FL sized many times fired, or new, Win brass, 28.0g AA2460, CCI400 primer. 2460 isn't a powder I see in many manuals for the .223, but it sure works like a death ray for PBR GH hunting - I've killed 34 of them with this load so far this summer. Note: For whatever unknown reason, this load doesn't work nearly as well with 40g V-Max or 40g Sierra BK.
I've also seen a .22-250 load for the 55g NBT (came to my friend in MN out of a magazine article, he e-mailed it to me, I tried it, it works great for hunting) that seems to shoot in about anything I try it in (Savage LRPV set back to 24" barrel, Savage BVSS with 26" barrel, Winchester Coyote with 24" barrel). I haven't tried it in a Remington yet, but I may get a chance to do that yet this summer. Limited sample, all heavy barrels, but it shoots holes touching in all three.
And then I've seen rifles that wouldn't shoot anything well no matter what I did, till I rebarreled them.
I've also seen people shoot barrels to death looking for a load with no chance of succeeding because they ate the throat out of their rifle 1,00 rounds into their 3,000 round load testing marathon searching for the perfect load, then claim the rifle was a POS. Go figure?
Fitch