tazman,
A group can't get smaller with more shots, so if the first two shots don't show something promising and there is no other explanation (wind puff or gun handling) you can move on without pounding three more shots just for the heck of it. As you refine your opinion of what's going to work with two and three shot groups you can increase to five shot groups. Five shot groups are still not statistically valid but the objective is to get the rifle shooting near its potential before we wear it out or run out of money for components and have nothing left to shoot in matches, not scientific proof of the absolute ultimate load which changes a tiny amount with each shot as the barrel is consumed anyway.
In short range benchrest with small cases, high load density is shown to be an important contributor to top accuracy while charge uniformity is lower on the list. Short range competitors quite happily and successfully dump charges straight from the measure into a case. Conversely, the larger, often much larger cases used in long range benchrest seem to be less responsive to load density but demand absolute consistency in charge weight. Long range shooters find greater success by weighing each charge, some of them to the nearest kernel of powder, plus or minus 0.2 grain. Part of this difference is due to the more consistent metering of the powders used in short range but part of it is not. Very low velocity extreme spread is an important indicator for long range accuracy but not so much in short range.
The 300 Ackley (300 Weatherby Improved) is a very well established and popular chamber for 1K competition that has low load density regardless of chosen powder. Probably as many competitors find success with RL22 as do with the bulkier RL25. Bob Rosen and I think Danny Brooks use 4350 in the 300 Win Mag to great effect and this choice leaves a lot more space in the case than other, slower powder choices will. In the early days of 600 yd IBS, I set a couple of single target records with Varget in a 6-250 improved. Varget is "too fast" for that loading and left lots of room in the case. Point is, don't worry about load density at 1K. Its about tenth on a list of three things that are crucial for good results.
Pick a powder and bullet (which you have done) and get that working for you.
Greg