FWIW from a relative rookie BR shooter who happens to be lucky enough to have access to a gun that will put a bullet where you want it to go.
bullets just off the lands or touching. powder charge 10% below published or known safe maximum. Pick a primer that is appropriate and shoot five (or 3 if they won't touch right off). Go up in charge by 0.3 or 0.5gr until you reach a load that will bring 5 shots into a nice ragged hole, or at least will go where the wind is supposed to put them, and then adjust seating depth.
Keep primers a constant. Try different bullet weights if you can't get 5 shots to go where you want them to after varying seating depth. I have tried to use known standard bullets that seem to shoot well, maybe not the absolute peak of accuracy, but will give me an honest estimation of my guns ability (like a 69gr sierra in a 1:9 .223 or BIB 118's in my 30BR). An important thing to note is that judging a load without wind flags will drive you nuts...was it the wind that put that shot out of the group, a handling error or is this load not worth the barrel life you just burned up.
I don't know what your background is, but if you have a stick and some surveyors tape you have wind flags in the making and will vastly improve your group size.
Hope this helps,
Mike