Jerry........
If you have an 8 twist, you may have a long throat as well, which may aid you in making a decision on bullet choice.
I have a buddy in Va. that loaded the 75g V max in his 22/250, and he said that the bullet did not kill worth a darn and gave them up. He said that chucks kept making it back to their hole, acting as if they had never been hit.
Some guys have reported great success with the 75g A-Max while others report dismal terminal effects...it's your time to be the experimentor if you do decide to go that direction.
In my 223 AI, I load of 28.5g of N-135 with the 55 Nosler Ballistic tip in IMI brass with a 7 1/2 primer at 3550 fps out of a 27" Hart 14 twist MHV barrel with zero freebore. I would not suggest that you use anything but IMI or Lapua brass with this load and start off at 27.0g and go up to as pressure allows. I shot this load again today and accuracy is amazing in my rifle with the cases only needing neck siziing after firing. 28.5g of N-135 is a compressed load and is put in the case slowly. Loading this load is a pain, but shooting bug hole groups with 55g Noslers makes it worth the effort.
Good luck!